BMI1
-
Official Full Name
BMI1 polycomb ring finger oncogene -
Overview
BMI1 polycomb ring finger oncogene, also known as BMI1, is a protein which in humans is encoded by the BMI1 gene. -
Synonyms
BMI1;BMI1 polycomb ring finger oncogene;PCGF4;RNF51;MGC12685;FLVI2/BMI1;B lymphoma Mo-MLV insertion region 1 homolog (mouse);polycomb group ring finger 4;Polycomb complex protein BMI-1;Polycomb group RING finger protein 4;RING finger protein 51;flvi-2/bmi-1;OTTHUMP00000019290;OTTHUMP00000019293;polycomb group protein Bmi1;B lymphoma Mo-MLV insertion region 1 homolog;murine leukemia viral (bmi-1) oncogene homolog
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Arg
- Non
- His&MBP
- His&Fc&Avi
Involved Pathway
BMI1 involved in several pathways and played different roles in them. We selected most pathways BMI1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells,Transcriptional misregulation in cancer,MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with BMI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | NFKB1,MYCN,HOXA10,BMP2K,PBX3,HOXA9,MET,FUS,FCGR1,HDAC1 |
| MicroRNAs in cancer | CYP24A1,ST14,ITGA5,EZH2,DNMT1,IRS1,DNMT3A,PDGFRA,HRAS,WNT3 |
| Signaling pathways regulating pluripotency of stem cells | PCGF5,FZD9,NEUROG1,MAPK1,PIK3R1,HRAS,BMP4,PIK3CB,SMAD3,BMPR1A |
Protein Function
BMI1 has several biochemical functions, for example, RING-like zinc finger domain binding,protein binding,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BMI1 itself. We selected most functions BMI1 had, and list some proteins which have the same functions with BMI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | CXXC5,TRIM13,TRIM59,USP22,BBOX1,DTX1,POLR2L,PRICKLE1,RARG,MMP10 |
| RING-like zinc finger domain binding | RNF2,UBE2I |
| protein binding | CROP,LSM7,HMGB3,GEMIN8,FGA,DAB2,BEX1,PARK2,SUMO1,MTMR9 |
Interacting Protein
BMI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BMI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BMI1.
RNF2;RING1
Resources
Research Area
Histone UbiquitylationHematopoietic Stem Cell Markers
Intestinal Stem Cell Markers
Epigenetics and EMT
Neural Stem Cell Markers
Head and Neck Cancer Stem Cell Markers
Leukemia Cancer Stem Cell Markers
Prostate Cancer Stem Cell Markers
Breast Cancer Stem Cell Markers
Glioma/Medulloblastoma Cancer Stem Cell Markers
Pancreatic Cancer Stem Cell Markers
Head and Neck Cancer Biomarkers
Related Services
Related Products
References
- Sun, J; Wang, J; et al. Knockdown of Polycomb-Group RING Finger 6 Modulates Mouse Male Germ Cell Differentiation in Vitro. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 35:339-352(2015).
- Jagtap, JC; Dawood, P; et al. Expression and Regulation of Prostate Apoptosis Response-4 (Par-4) in Human Glioma Stem Cells in Drug-Induced Apoptosis. PLOS ONE 9:-(2014).
