BGN
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Official Full Name
biglycan -
Overview
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009] -
Synonyms
BGN;biglycan;PGI;DSPG1;PG-S1;SLRR1A;biglycan proteoglycan;bone/cartilage proteoglycan I;bone/cartilage proteoglycan-I;small leucine-rich protein 1A;dermatan sulphate proteoglycan I
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Wheat Germ
- HEK293
- Human Cell
- Mammalian Cell
- CHO
- Mammalian cells
- In Vitro Cell Free System
- His
- GST
- Non
- Fc
- His&Myc&SUMO
- His&Fc&Avi
Involved Pathway
BGN involved in several pathways and played different roles in them. We selected most pathways BGN participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis,CS/DS degradation,Chondroitin sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BGN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Defective B3GAT3 causes JDSSDHD | BCAN,CSPG4,AGRN,CSPG5,VCAN,DCN,GPC6,NCAN,GPC5 |
| Defective CHST14 causes EDS, musculocontractural type | BCAN,DCN,CSPG4,CSPG5 |
| Defective B3GALT6 causes EDSP2 and SEMDJL1 | BCAN,GPC6,CSPG4,AGRN,VCAN,CSPG5,DCN,GPC5,NCAN |
| Defective B4GALT7 causes EDS, progeroid type | DCN,GPC5,NCAN,BCAN,AGRN,CSPG5,VCAN,CSPG4,GPC6 |
| Chondroitin sulfate/dermatan sulfate metabolism | BGNB,DCN,VCAN,UST,CSPG5,VCANB,NCAN,B4GALT7,DSEL,AGRN |
| chondroitin sulfate biosynthesis | BCAN,BGNB,DCN,UST,NCAN,CSPG5,CSPG5B,B3GAT2,CSPG4,VCANB |
| CS/DS degradation | BGNA,BGNB,VCANB,CSPG4,BCAN,DCN,NCAN,CSPG5,CSPG5B,VCAN |
| A tetrasaccharide linker sequence is required for GAG synthesis | GPC1A,CSPG5B,BCAN,VCANB,CSPG5,Gpc2,VCAN,DCN,NCAN,B4GALT7 |
Protein Function
BGN has several biochemical functions, for example, extracellular matrix binding,extracellular matrix structural constituent,glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BGN itself. We selected most functions BGN had, and list some proteins which have the same functions with BGN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix structural constituent | COL1A1A,FBN1,ACAN,EFEMP2,COL1A1,OPTC,COMP,COL4A6,CD4,LAMC1 |
| extracellular matrix binding | SPP1,DMP1,SPARC,CD248,ITGA2B,FBLN2,DCN,ITGB3,CYR61,VEGFA |
| glycosaminoglycan binding | ENG,EGFLAM,SPOCK2,VIT,EPYC,HABP2,SPOCK3,DCN,SERPINE2,SERPINA5 |
Interacting Protein
BGN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BGN here. Most of them are supplied by our site. Hope this information will be useful for your research of BGN.
TLR4;TLR2;PCOLCE;vegfa mouse;NUDCD2;Tlr4;Tlr2;Enam;prfA;Ambn;Amelx;q7ard3_yerpe;q7cg01_yerpe;fabG7
Resources
Research Area
Osteoclast MarkersWnt Signaling Modulators
Other Secreted VSMC Molecules
Osteoblast and Osteoclast Markers
Osteogenesis Markers
Proteoglycans
Osteocyte Markers
Proteoglycan
Related Services
Related Products
References
- Berendsen, AD; Pinnow, EL; et al. Biglycan modulates angiogenesis and bone formation during fracture healing. MATRIX BIOLOGY 35:223-231(2014).
- Dupuis, LE; Kern, CB; et al. Small Leucine- Rich Proteoglycans Exhibit Unique Spatiotemporal Expression Profiles During Cardiac Valve Development. DEVELOPMENTAL DYNAMICS 243:601-611(2014).
