BCL2L1
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Official Full Name
BCL2-like 1 -
Overview
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008] -
Synonyms
BCL2L1;BCL2-like 1;BCLX;BCL2L;BCLXL;BCLXS;Bcl-X;bcl-xL;bcl-xS;PPP1R52;BCL-XL/S;bcl-2-like protein 1;apoptosis regulator Bcl-X;protein phosphatase 1, regulatory subunit 52
Recombinant Proteins
- Human
- Rat
- Chicken
- Rhesus macaque
- Mouse
- Zebrafish
- Mus musculus
- Sus scrofa (Pig)
- E. coli
- E.coli
- Wheat Germ
- Mammalian Cell
- Insect Cell
- HEK293
- In Vitro Cell Free System
- Mammalian cells
- HEK293T
- E.coli expression system
- His
- GST
- Non
- His&SUMO
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
BCL2L1 involved in several pathways and played different roles in them. We selected most pathways BCL2L1 participated on our site, such as Ras signaling pathway,NF-kappa B signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BCL2L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chronic myeloid leukemia | PIK3CD,MDM2,TP53,STAT5A,MAPK1,CBL,SMAD3,NRAS,KRAS,PIK3R3 |
| Toxoplasmosis | MAPK8,IFNGR1,CD40LG,CYCS,PPIF,PDPK1,PIK3R3,TGFB1,NFKBIB,Casp3 |
| Amyotrophic lateral sclerosis (ALS) | BID,CCS,PPP3R1,TP53,GRIN2B,CASP12,CASP1,TNFRSF1A,CAT,RAC1 |
| HTLV-I infection | CD3E,HLA-DPA1,FZD5,FZD2,FOSL1,WNT16,MAP3K3,SLC2A1,TBPL1,TNF |
| Pathways in cancer | PTCH2,FH1,MAPK10,PTGER1,FGF16,WNT10B,RALB,TRAF1,NFKB1,PRKCG |
| Small cell lung cancer | LAMA2,LAMA1,CCNE2,TP53,LAMB3,COL4A1,RXRB,IKBKG,LAMB1,LAMA5 |
| Ras signaling pathway | GNG10,SHC2,PLA2G5,RASGRP3,PRKACB,FGF17,FGF3,Fgf15,RHOA,FGF22 |
| Apoptosis | IL3,CAPN1A,CASP3A,HELLS,AKT3A,BIRC3,PKP1,PRKACA,FADD,DCC |
| Jak-STAT signaling pathway | IL11RA2,GHR,PIK3CB,IL13,IL3RA,OSM,GFAP,CRLF2,CSF3,IL20RB |
Protein Function
BCL2L1 has several biochemical functions, for example, BH3 domain binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BCL2L1 itself. We selected most functions BCL2L1 had, and list some proteins which have the same functions with BCL2L1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | RCC2,CDC25A,E2F1,GHR,FBXO5,SNAP91,POLA1,SHC3,JTB,NPR1 |
| protein binding | SERPINF2,AGR2,C16orf87,SEMA4D,MXD1,KRT7,NCAPD2,NKX3-1,CNKSR1,GLE1 |
| protein homodimerization activity | Trl,SYT16,UNC13A,CD226,ADD2,FLRT3,ASMT,IKZF2,HLA-G,BST2 |
| identical protein binding | KHDC1A,DYNLT1B,NUDT16,GOT1,ZDHHC17,TOPBP1,UAP1,B2M,PLEKHH2,ALDH4A1 |
| protein heterodimerization activity | GABPA,KCNB1,NPAS4,CHRNB4,PRMT5,UBXN6,TIMELESS,YWHAE,ATF4,ANO9A |
| BH3 domain binding | MCL1,BCL2,BAX |
Interacting Protein
BCL2L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BCL2L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of BCL2L1.
BAD;BAX;NLRP1
BCL2L1 Related Signal Pathway
Resources
Research Area
Bcl-2 FamilyInflammasome
Natural Killer T (NKT) Cells
Mediators in B Cell Development
Other Autophagy-related Proteins
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References
- Garimella, SV; Gehlhaus, K; et al. Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening. BREAST CANCER RESEARCH 16:-(2014).
- Lee, BS; Cha, HY; et al. AY4, an agonistic anti-death receptor 4 MAB, induces apoptotic cell death in anaplastic thyroid cancer cells via downregulation of Bcl-xL with reactive oxygen species generation. ENDOCRINE-RELATED CANCER 20:283-291(2013).
