AURKB

  • Official Full Name

    aurora kinase B

  • Overview

    This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

  • Synonyms

    AURKB;aurora kinase B;AIK2;AIM1;ARK2;AurB;IPL1;STK5;AIM-1;STK12;PPP1R48;aurkb-sv1;aurkb-sv2;ARK-2;STK-1;aurora 1;aurora-1;aurora-B;aurora kinase B-Sv1;aurora kinase B-Sv2;aurora-related kinase 2;serine/threonine kinase 12;aurora/IPL1-related kinase 2;serine/threonine-protein kinase 5;serine/threonine-protein kinase 12;serine/threonine-protein kinase aurora-B;protein phosphatase 1, regulatory subunit 48;aurora- and Ipl1-like midbody-associated protein 1

Recombinant Proteins

  • Human
  • Zebrafish
  • Mouse
  • Rat
  • E.coli
  • Wheat Germ
  • Mammalian Cell
  • Sf9 Insect Cell
  • Insect Cell
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • HEK293T
  • Insect (sf21)
  • Mamanlian cells
  • His
  • GST
  • Non
  • His&Flag
  • Myc&DDK
  • Flag
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
AURKB-231H Recombinant Human Aurora Kinase B, His-tagged E.coli Human His
AURKB-3924H Recombinant Human AURKB protein, His-tagged E.coli Human His 1-371 aa
AURKB-1038H Recombinant Human AURKB protein, GST-tagged Wheat Germ Human GST
AURKB-11846Z Recombinant Zebrafish AURKB Mammalian Cell Zebrafish His
AURKB-2207M Recombinant Mouse AURKB Protein Mammalian Cell Mouse His
AURKB-247H Recombinant Human Aurora Kinase B, GST-tagged, Active Sf9 Insect Cell Human GST
AURKB-26601TH Recombinant Human AURKB Human Non Full L.
AURKB-27422TH Recombinant Human AURKB, His-tagged Human His 2-344 a.a.
AURKB-35H Recombinant Human AURKB/INCENP protein, Flag/His-tagged, Biotinylated Insect Cell Human His&Flag 1-344;803-918 a.a.
Aurkb-3781M Recombinant Mouse Aurkb, His-tagged E.Coli or Yeast Mouse His 345
AURKB-46H Recombinant Human AURKB protein, MYC/DDK-tagged HEK293 Human Myc&DDK
AURKB-5292H Recombinant Human Aurora Kinase B Sf9 Insect Cell Human Non
AURKB-684H Recombinant Human Aurora Kinase B, GST-His Human GST 2-344 a.a.
AURKB-904R Recombinant Rat AURKB Protein Mammalian Cell Rat His
AURORA B-3778H Recombinant Human AURORA B protein, GST-tagged Insect Cell Human GST full-length
AURKB-8560HCL Recombinant Human AURKB 293 Cell Lysate HEK293 Human Non
AURKB-05H Recombinant Human AURKB (D200A) Mutant Protein, GST-tagged Insect Cell Human GST
AURKB-1104HF Recombinant Full Length Human AURKB Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 344 amino acids
AURKB-1112H Recombinant Human AURKB Protein (A2-A344), Tag Free Insect Cell Human Non A2-A344
AURKB-1113H Recombinant Human AURKB Protein (A2-A344), GST tagged Insect Cell Human GST A2-A344
Aurkb-1789M Recombinant Mouse Aurkb Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
Aurkb-279R Recombinant Rat Aurkb Protein, His-tagged E.coli Rat His Gly92-Pro339
AURKB-4230HF Active Recombinant Full Length Human AURKB Protein, DDK-tagged, Biotinylated Insect (sf21) Human Flag Full L. 1-344(end)
AURKB-5410H Recombinant Human AURKB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
AURKB-560R Recombinant Rat AURKB Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
AURKB-560R-B Recombinant Rat AURKB Protein Pre-coupled Magnetic Beads HEK293 Rat
AURKB-8990HF Active Recombinant Full Length Human AURKB Protein, GST-tagged Insect (sf21) Human GST Full L. 1-344(end)
AURKB-909M Recombinant Mouse AURKB Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
AURKB-909M-B Recombinant Mouse AURKB Protein Pre-coupled Magnetic Beads HEK293 Mouse
AURKB-9695HFL Recombinant Full Length Human AURKB protein, Flag-tagged Mamanlian cells Human Flag Full L.

    Involved Pathway

    AURKB involved in several pathways and played different roles in them. We selected most pathways AURKB participated on our site, such as APC/C-mediated degradation of cell cycle proteins,APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1,Aurora A signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AURKB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aurora A signaling AURKAIP1,TPX2,TDRD7,CENPA,GADD45A,NDEL1,TACC3,OAZ1,TACC1
    FOXM1 transcription factor network CHEK2,CENPA,CENPB,CKS1B,FOXM1
    Aurora C signaling AURKC,INCENP
    APC/C-mediated degradation of cell cycle proteins PSMD14,PSMD5,NEK2,PSMA8,PSMD9,PSME3,UBE2C,ANAPC10,CDK2,PSMD10
    Aurora B signaling KIF2C,AURKC,NPM1,NDC80,SMC4,NCAPD2,EVI5,PEBP1,CDCA8,SEPT1
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 PSMD5,UBE2C,PSME3,PSMD14,PSMD10,PSMD9,ANAPC10,PSMA8
    Cell Cycle, Mitotic CTDNEP1B,NCAPH,LMNB1,SET,SKA1,CLASP1A,CDCA8,CTDNEP1,CENPL,GOLGA2
    Cell cycle KIF2C,FZR1,FOXM1,STAG2,KIF20A,NEK7,MPEG1,TINF2,CEP78,TOP2A

    Protein Function

    AURKB has several biochemical functions, for example, ATP binding,histone serine kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AURKB itself. We selected most functions AURKB had, and list some proteins which have the same functions with AURKB. You can find most of the proteins on our site.

    Function Related Protein
    protein binding FTSJ3,LIN37,BBS1,DDX3X,CLOCKB,ARFGAP3,ID4,TAC1,TPSB2,SELS
    metal ion binding EPX,ZNFL2A,RPP21,ZFP804A,ARSI,DNMT3L,PRDM14,ZBTB24,DGKQ,RARAA
    ATP binding LIMK1,CDK10,ATP7B,HELB,EPHA3,C22orf28,ATP9A,PET112L,SLC14A2,CENPE
    protein serine/threonine kinase activity TLK2,MINK1,AKT3,PRKCBB,BMPR1BA,CAMK1GA,RPS6KB2,DMPK,OBSCN,SRPK3
    histone serine kinase activity PRKAA2,AURKA,AURKC,PRKAA1,ATM
    protein serine/threonine/tyrosine kinase activity MAP2K2,TESK1,CLK1,RPS6KA2,AKT1,PRKACA,RPS6KB1,DYRK1A,MAP2K1,DSTYK

    Interacting Protein

    AURKB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AURKB here. Most of them are supplied by our site. Hope this information will be useful for your research of AURKB.

    BIRC5;INCENP;SEPT1

    Resources

    Research Area

    Cancer Drug Targets
    Histone Phosphorylation
    Microtubules
    Metaphase (Mitotic Spindle) Checkpoints

    References

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