ATG4B
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Official Full Name
autophagy related 4B, cysteine peptidase -
Overview
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] -
Synonyms
ATG4B;autophagy related 4B, cysteine peptidase;APG4B;AUTL1;cysteine protease ATG4B;hAPG4B;autophagin-1;APG4 autophagy 4 homolog B;AUT-like 1 cysteine endopeptidase;ATG4 autophagy related 4 homolog B;autophagy-related protein 4 homolog B;autophagy-related cysteine endopeptidase 1
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
ATG4B involved in several pathways and played different roles in them. We selected most pathways ATG4B participated on our site, such as Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATG4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of autophagy | INS1,ATG12,GABARAPA,GABARAP,ATG7,IFNA10,GABARAPL1,Ifna11,IFNA6,GABARAPL2 |
Protein Function
ATG4B has several biochemical functions, for example, cysteine-type endopeptidase activity,cysteine-type peptidase activity,endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATG4B itself. We selected most functions ATG4B had, and list some proteins which have the same functions with ATG4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase activity | CTSZ,CASPA,USP8,CTSSB.1,CASP10,BLMH,USP37,USP4,CTSW,CASP3B |
| protein binding | GATC,ADRB1,MIA3,PTPRM,RASGRP3,RANBP2,SYNE3,CDCA4,DDX31,EIF4A1 |
| cysteine-type peptidase activity | SENP7B,CTSC,CTSJ,CTSB,USP43A,USP9,CTSBB,CASPA,CTSL1B,BLMH |
| endopeptidase activity | KLK1B24,PARL,PSMB8,ELANE,ECE1,PSMB11,RHBDD1,MMP9,PSMB4,PSMB7 |
Interacting Protein
ATG4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATG4B here. Most of them are supplied by our site. Hope this information will be useful for your research of ATG4B.
MAP1LC3B;GABARAPL2;GABARAP
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