ATG16L1
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Official Full Name
autophagy related 16-like 1 (S. cerevisiae) -
Overview
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010] -
Synonyms
ATG16L1;autophagy related 16-like 1 (S. cerevisiae);IBD10;WDR30;APG16L;ATG16A;ATG16L;autophagy-related protein 16-1;APG16L beta;WD repeat domain 30;ATG16 autophagy related 16-like 1
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Wheat Germ
- Mammalian Cell
- E.coli
- In Vitro Cell Free System
- HEK293
- Yeast
- GST
- His
- Non
- His&GST
- His&T7
- His&Fc&Avi
- His&SUMO
Involved Pathway
ATG16L1 involved in several pathways and played different roles in them. We selected most pathways ATG16L1 participated on our site, such as Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATG16L1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of autophagy | IFNA17,IFNA16,IFNPHI3,BECN1,ATG13,INS2,ATG4B,IFNA13,INS,INSB |
Protein Function
ATG16L1 has several biochemical functions, for example, identical protein binding,protein binding,ubiquitin-like protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ATG16L1 itself. We selected most functions ATG16L1 had, and list some proteins which have the same functions with ATG16L1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PTK7,EDC3,ZHX3,HFE2,ZNF397,SCAMP5,MKRN3,PPIL3,CDK15,MARVELD3 |
| ubiquitin-like protein transferase activity | RNF14,RNF139,ARIH1,UBL4A,ATG3 |
| identical protein binding | FGFR1,PIK3AP1,ASMT,AGXT2L1,GRB7,MRI1,SNRNP200,PCNA,DPP4,PTK6 |
Interacting Protein
ATG16L1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATG16L1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATG16L1.
RB1CC1;ATG5;ATG12;MAP1LC3C;TMEM59
Resources
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References
- Ciccacci, C; Perricone, C; et al. A Multilocus Genetic Study in a Cohort of Italian SLE Patients Confirms the Association with STAT4 Gene and Describes a New Association with HCP5 Gene. PLOS ONE 9:-(2014).
- Lee, KM; Lee, JM; et al. Crohn's disease in Korea: past, present, and future. KOREAN JOURNAL OF INTERNAL MEDICINE 29:558-570(2014).
