ASCL1
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Official Full Name
achaete-scute family bHLH transcription factor 1 -
Overview
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5-CANNTG-3). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008] -
Synonyms
ASCL1;achaete-scute family bHLH transcription factor 1;ASH1;HASH1;MASH1;bHLHa46;achaete-scute homolog 1;ASH-1;achaete scute protein;achaete-scute complex-like 1;achaete-scute complex homolog 1;class A basic helix-loop-helix protein 46
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- E. coli
- Arg
- His
- Non
- GST
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
ASCL1 involved in several pathways and played different roles in them. We selected most pathways ASCL1 participated on our site, such as Delta-Notch Signaling Pathway,Neural Crest Differentiation,Notch-mediated HES/HEY network, which may be useful for your reference. Also, other proteins which involved in the same pathway with ASCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch-mediated HES/HEY network | GATA6,BGLAP,CTBP1,HEY1,MYB,YY1,RCAN1,GATA1,HES6,MYOD1 |
| Neural Crest Differentiation | TFAP2A,SOX5,TXLNB,DLX5,SOX10,HOXA1,MBP,PRTG,OLIG3,TBX6 |
| SIDS Susceptibility Pathways | FOXM1,LMX1B,PKNOX1,KCNH2,KCNJ8,TSPYL1,POU2F2,PLP1,TAC1,MAZ |
| Delta-Notch Signaling Pathway | CNTFR,JAG1,WDR12,YY1,YY1A,ZFPM1,CNTN1B,HIVEP3,TLE1,MAGEA1 |
Protein Function
ASCL1 has several biochemical functions, for example, DNA binding,E-box binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ASCL1 itself. We selected most functions ASCL1 had, and list some proteins which have the same functions with ASCL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | PON3,SNX2,DPP4,Il6ra,ABCD1,PDGFA,VPS24,TCF3A,RPE,VOX |
| E-box binding | BHLHE40,ARNTL,ZEB1,NEUROG2,ARNTL2,NEUROG1,TAL1,TCF4,TCF3,ASCL2 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | ZKSCAN3,NR2E1,PROX2,NR2C1,NFATC2,EN1,HHEX,GZF1,AEBP2,CTCF |
| bHLH transcription factor binding | TCF3,MAP3K10,TWIST1,LMO2,USF2,USF1,SP1,EP300,FOXH1,PSMD9 |
| transcription factor activity, transcription factor binding | HIF1A,PER2,ASCL1A,MTA2,CRY1,LDB1B,LDB2A,CRY2,ASCL1B,NEUROG1 |
| transcription factor activity, sequence-specific DNA binding | MEF2A,STAT5B,FOXB1A,CSRNP1,ZIK1,ZFP382,ZNF615,ZFP131,ZFP821,REL |
| chromatin binding | HMGA1,DNMT3A,BARX2,CBX4,PRKCBP1L,RDBP,BRD2,DNMT1,MSL1,Ar |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | SPI1,ZNF543,FEZF2,SMAD1,HNRNPC,HHEX,NFIC,GLI3,IRF1,ZNF148 |
| protein binding | SP100,BLZF1,DHX9,EDA2R,KCNQ1,TLR4,NCF4,KIF5C,SPINK7,DYNC1H1 |
Interacting Protein
ASCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ASCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ASCL1.
TCF4;TCF3;dna-1
Resources
Research Area
Transcription Factors in the Akt PathwayCancer Stem Cell Transcription Factors
Neural Stem Cell Transcription Factors
Wnt Intracellular Signaling
Neural Stem Cell Markers
Neural Crest Cell Markers
Glioma Biomarkers
Related Services
Related Products
References
- Karow, M; Schichor, C; et al. Lineage-reprogramming of Pericyte-derived Cells of the Adult Human Brain into Induced Neurons. Jove-Journal of Visualized Experiments :-(2014).
- Teicher, BA; et al. Targets in small cell lung cancer. BIOCHEMICAL PHARMACOLOGY 87:211-219(2014).
