ARHGAP1
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Official Full Name
Rho GTPase activating protein 1 -
Overview
Rho GTPase-activating protein 1 is an enzyme that in humans is encoded by the ARHGAP1 gene. -
Synonyms
ARHGAP1;Rho GTPase activating protein 1;rho GTPase-activating protein 1;Cdc42GAP;p50rhoGAP;RhoGAP;ARHGAP 1;CDC42 GTPase activating protein;GTPase activating protein rhoOGAP;OTTHUMP00000233485;OTTHUMP00000233486;p50 RhoGAP;Rho related small GTPase protein activator;Rho type GTPase activating protein 1;RHOGAP1;p50-RhoGAP;CDC42 GTPase-activating protein;GTPase-activating protein rhoOGAP;rho-type GTPase-activating protein 1;rho-related small GTPase protein activator
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
ARHGAP1 involved in several pathways and played different roles in them. We selected most pathways ARHGAP1 participated on our site, such as Regulation of CDC42 activity,Regulation of RAC1 activity,Rho GTPase cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of RAC1 activity | ARHGEF25,RAP1GDS1,CHN2,ARHGAP9,EPS8,ARHGAP17,RALBP1,DOCK6,DEF6,ABR |
| Rho GTPase cycle | OPHN1,OBSCN,MYO9B,ARHGEF1A,FGD4,ARHGEF18A,RHOU,ARHGAP4A,ARHGAP29,ARHGAP10 |
| Signal Transduction | METAP2B,NMU,APOM,CCNT2B,RHOV,TTC21B,SPRY1,MLN,WLS,RBP1 |
| Regulation of CDC42 activity | ARHGEF25,BCAR3,MCF2L,DNMBP,DOCK9,SPATA13,DOCK10,ITSN2,ARHGAP17,RALBP1 |
| Signaling by Rho GTPases | ARAP1,RHOJ,RHOF,ARHGEF18A,DEPDC1B,TAGAP1,RHOT1,ARHGAP20,TAGAPA,ARHGAP6 |
Protein Function
ARHGAP1 has several biochemical functions, for example, GTPase activator activity,SH3 domain binding,SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP1 itself. We selected most functions ARHGAP1 had, and list some proteins which have the same functions with ARHGAP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | AKTIP,KLF2,CYCS,FZR1,XPO1,RUNX2,HAND1,RAD18,LIN28B,NGB |
| SH3 domain binding | PARK2,EPS15,ILK,SH3BP5LA,ZFP106,PTTG2,PLSCR3,EFS,QKI2,ADAM15 |
| SH3/SH2 adaptor activity | GRB10,SHB,SH2D3C,SKAP1,PAG1,SLA,GRB14,CRK,GRB2,SH3BGR |
| GTPase activator activity | ELMOD1,TSC2,CDC42EP1,SMAP1,RGS2,TIAM2,RGS9A,AGAP2,ARAP1,DOCK1 |
Interacting Protein
ARHGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP1.
CDC42;RHOA;CDC42;CHEK2;RHOC;AGTRAP;q8d0i9_yerpe;pi3p;1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate;ere_dna;STK4
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References
- Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).
- Navarrete-Perea, J; Moguel, B; et al. Identification and quantification of host proteins in the vesicular fluid of porcine Taenia solium cysticerci. EXPERIMENTAL PARASITOLOGY 143:11-17(2014).
