APOC1
-
Official Full Name
apolipoprotein C-I -
Overview
The protein encoded by this gene is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. -
Synonyms
APOC1;apolipoprotein C-I;apo-CIB;apoC-IB;apolipoprotein C1
Recombinant Proteins
- Mouse
- Dog
- Human
- Rat
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Human Plasma
- Wheat Germ
- In Vitro Cell Free System
- Mammalian cells
- HEK293
- HEK293T
- Human plasma
- His&GST
- His
- GST
- Non
- Flag
- Myc&DDK
- His&SUMO
- His&Fc&Avi
- Fc
Involved Pathway
APOC1 involved in several pathways and played different roles in them. We selected most pathways APOC1 participated on our site, such as Statin Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with APOC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Statin Pathway | APOC4,CETP,PDIA2 |
Protein Function
APOC1 has several biochemical functions, for example, fatty acid binding,lipase inhibitor activity,phosphatidylcholine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APOC1 itself. We selected most functions APOC1 had, and list some proteins which have the same functions with APOC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatidylcholine binding | NF1,CETP,RASGRP1,APOA4B.1,PCTP,GPR12,APOA4A,CHMP3,CHMP2A,APOA4 |
| lipase inhibitor activity | FAF2,APOC2,APOA1,APOA2,APOC3 |
| phosphatidylcholine-sterol O-acyltransferase activator activity | APOEA,APOA1,APOE,APOA1A,APOA2,APOA4,APOA5,APOA4B.1,APOA4A,APOA4B.2 |
| fatty acid binding | O3far1,FABP5,FABP1,FABP1B.1,HNF4A,ADH5,FABP7B,CYP4A14,FABP7A,FABP2 |
| phospholipase inhibitor activity | ANXA2A,ANXA1C,ANXA3B,ANXA2B,ANXA1B,ANXA5,SNCB,ANGPTL3,ANXA3A,ANXA1A |
Interacting Protein
APOC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APOC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of APOC1.
NSG2;d-mannose;IGHG1;IGHA1;APOA1;ALB
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