ANGPTL3
-
Official Full Name
angiopoietin-like 3 -
Overview
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013] -
Synonyms
ANGPTL3;angiopoietin-like 3;ANL3;ANG-5;FHBL2;ANGPT5;angiopoietin-related protein 3;angiopoietin 5
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- Chicken
- Zebrafish
- E.coli
- CHO
- Hamster
- C-His
- HEK293
- Mammalian Cell
- Wheat Germ
- In Vitro Cell Free System
- HEK293T
- NS0
- Mammalian cells
- Baculovirus-Insect Cells
- Insect Cell
- GST
- His
- His&Avi
- His&GST
- His&T7
- Flag
- FLAG
- Non
- Myc&DDK
- HA
- Fc
- His&Fc&Avi
Involved Pathway
ANGPTL3 involved in several pathways and played different roles in them. We selected most pathways ANGPTL3 participated on our site, such as Integrins in angiogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPTL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Integrins in angiogenesis | CSF1,CSF1R,MFGE8,EDIL3 |
Protein Function
ANGPTL3 has several biochemical functions, for example, enzyme inhibitor activity,growth factor activity,integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPTL3 itself. We selected most functions ANGPTL3 had, and list some proteins which have the same functions with ANGPTL3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | TIMP2,NOV,COL4A3,ACTN1,WISP2,LAMB2,ADAM2,JAM3,KDR,GPNMB |
| enzyme inhibitor activity | PLN,PRPSAP1,PPP1R12A,OAZ1A,UGT1A9,OAZ2A,CD46,APBA3,ANGPTL4,FRY |
| phospholipase inhibitor activity | ANXA1C,APOC1,ANXA2B,ANXA4,SNCB,ANXA3B,ANXA2A,ANXA1B,ANXA3A,ANXA1A |
| growth factor activity | INHBA,NDP,TGFB1A,TYMP,PPBP,CNTF,COL20A1,GPR19,CTGF,LEFTY2 |
Interacting Protein
ANGPTL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPTL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPTL3.
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References
- Nakajima, K; Kobayashi, J; et al. Antibodies to human angiopoietin-like protein 3: a patent evaluation of WO2012174178. EXPERT OPINION ON THERAPEUTIC PATENTS 24:113-119(2014).
- Chou, S; Lodish, HF; et al. Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:7799-7804(2010).
