ALKBH3
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Official Full Name
alkB, alkylation repair homolog 3 (E. coli) -
Overview
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA;lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the;removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 (PubMed 12486230)). -
Synonyms
ALKBH3;alkB, alkylation repair homolog 3 (E. coli);alpha-ketoglutarate-dependent dioxygenase alkB homolog 3;DEPC 1;prostate cancer antigen 1;prostate cancer antigen-1;alkylated DNA repair protein alkB homolog 3;ABH3;PCA1;DEPC1;DEPC-1;FLJ43614;MGC118790;MGC118792;MGC118793
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
- His&SUMO
Involved Pathway
ALKBH3 involved in several pathways and played different roles in them. We selected most pathways ALKBH3 participated on our site, such as ALKBH3 mediated reversal of alkylation damage,DNA Damage Reversal,DNA Repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALKBH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| DNA Repair | UIMC1,DCLRE1A,COPS3,FUZ,BRE,MAD2L2,EME2,EYA4,DDB2,ALKBH2 |
| ALKBH3 mediated reversal of alkylation damage | ASCC3,ASCC1,ASCC2 |
| Reversal of alkylation damage by DNA dioxygenases | ALKBH2,ASCC1,ASCC2,ASCC3 |
| DNA Damage Reversal | MGMT,ASCC1,ALKBH2,ASCC3,ASCC2 |
Protein Function
ALKBH3 has several biochemical functions, for example, DNA-N1-methyladenine dioxygenase activity,L-ascorbic acid binding,cytosine C-5 DNA demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALKBH3 itself. We selected most functions ALKBH3 had, and list some proteins which have the same functions with ALKBH3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA-N1-methyladenine dioxygenase activity | PHF2,KDM5BB,FTO,JMJD1C,ALKBH2,KDM5D |
| cytosine C-5 DNA demethylase activity | ALKBH2 |
| ferrous iron binding | NT5E,Trf,PLOD1,ALKBH2,TET2,TF,BCO1,EGLN2,FECH,SNCA |
| L-ascorbic acid binding | LEPRE1,PAM,P4HA2,EGLN2,FAM125B,P4HA1,OGFOD3,PLOD3,PLOD1,PLOD2 |
| protein binding | ZNF488,TELO2,C1orf116,MS4A1,RPL4,MLH1,SCO1,CPNE6,ACP1,IL18 |
Interacting Protein
ALKBH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALKBH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALKBH3.
GLRX3;GOLGA2;IKZF1;LNX1;AK8;SRPK2;SRPK1
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References
- Vagbo, CB; Svaasand, EK; et al. Methylation damage to RNA induced in vivo in Escherichia coli is repaired by endogenous AlkB as part of the adaptive response. DNA REPAIR 12:188-195(2013).
- Meza, TJ; Moen, MN; et al. The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. NUCLEIC ACIDS RESEARCH 40:6620-6631(2012).
