AKR1B1
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Official Full Name
aldo-keto reductase family 1, member B1 (aldose reductase) -
Overview
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009] -
Synonyms
AKR1B1;aldo-keto reductase family 1, member B1 (aldose reductase);AR;ADR;ALR2;ALDR1;aldose reductase;aldehyde reductase 1;low Km aldose reductase;Lii5-2 CTCL tumor antigen;aldo-keto reductase family 1 member B1
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- Wheat Germ
- Mammalian cells
- HEK293
- In Vitro Cell Free System
- HEK293T
- E. coli
- Non
- His
- GST
- Flag
- His&Fc&Avi
- Myc&DDK
- N-His
Involved Pathway
AKR1B1 involved in several pathways and played different roles in them. We selected most pathways AKR1B1 participated on our site, such as Pentose and glucuronate interconversions,Fructose and mannose metabolism,Galactose metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKR1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerolipid metabolism | ALDH2,DGAT1,MBOAT1,LPL,AGPAT9L,GPAT2,STIL,ALDH2.1,ALDH9A1B,DGAT1A |
| Metabolic pathways | POLR2A,PNP6,CYP2U1,ALOX5A,GALNT10,KDSR,ADSSL,PNP5A,ALPPL2,PPAP2CB |
| Fructose and mannose metabolism | TPI1B,PMM2,PFKL,SORD,AKR1B8,FBP1,AKR1B7,HKDC1,MPI,HK3 |
| Galactose metabolism | HK3,AKR1B1L,AKR1B8,GANC,PFKMA,G6PCA.1,G6PC3,B4GALT1,UGP2,GALE |
| Pentose and glucuronate interconversions | XYLB,SORD,AKR1A1A,GUSB,UGT5G1,GKUP,Akr1b3,ALDH3A2,UGT2B7,AKR1A1B |
Protein Function
AKR1B1 has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity,aldo-keto reductase (NADP) activity,electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKR1B1 itself. We selected most functions AKR1B1 had, and list some proteins which have the same functions with AKR1B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aldo-keto reductase (NADP) activity | HSD11B1LA,KCNAB1,HSD3B5,HSD3B6,AKR1C21,SPR,MIOX,AKR7A3,SDR16C6,CYB5A |
| alditol:NADP+ 1-oxidoreductase activity | AKR1C21,AKR1C3,PRKRA,AKR1B7,AKR7A2,AKR1A1,ADH4,AKR7A5,AKR1C2,AKR1B8 |
| glyceraldehyde oxidoreductase activity | Akr1b3 |
| electron carrier activity | SDHD,NDUFA12,NDUFS2,FDX1B,ETFA,GRX2,ACADL,DHRS3,AOC2,HAAO |
Interacting Protein
AKR1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKR1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKR1B1.
PRMT2;13529257;ZNF253;DSP;TFE3;MCC;PAX7;HLA-B;VHL;DST;IKBKE;CSMD1;TRAF6;SMAD1
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