AFP
-
Official Full Name
alpha-fetoprotein -
Overview
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008] -
Synonyms
AFP;alpha-fetoprotein;FETA;HPAFP;alpha-fetoglobulin;alpha-1-fetoprotein
Recombinant Proteins
- Human
- Cynomolgus
- Cattle
- Dog
- Mouse
- Pig
- Rat
- Canine
- Aspergillus giganteus
- HEK293
- C-His
- Human
- E.coli
- Mammalian Cells
- Human Cells
- E.Coli/Yeast
- Wheat Germ
- Human Cord Serum
- Yeast
- Insect Cells
- Human Cord Blood
- Human Fetal Cord Serum
- In Vitro Cell Free System
- His
- Non
- His&GST
- StrepII
- GST
- Myc&DDK
- Fc
- His&Fc&Avi
- His&B2M
- Flag
Involved Pathway
AFP involved in several pathways and played different roles in them. We selected most pathways AFP participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AFP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | RASSF1,BIRC2,PPP1CC,PPP2R2B,PARD6B,PPP2R1B,FZD6,GDF6,STK3,LIMD1 |
Protein Function
AFP has several biochemical functions, for example, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AFP itself. We selected most functions AFP had, and list some proteins which have the same functions with AFP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | FGD1,ZNF785,ZMYND17,NOX1,ING5B,MT1X,MORC1,ZFP36L1,EPX,RACGAP1 |
Interacting Protein
AFP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AFP here. Most of them are supplied by our site. Hope this information will be useful for your research of AFP.
Resources
Research Area
Early Endodermal Lineage MarkersLiver Cancer Stem Cell Markers
Endodermal Lineage Markers
Cancer Biomarkers in Clinical Practice
Head and Neck Cancer Biomarkers
Liver Cancer Biomarkers
Tumor Antigens
Related Services
Related Products
References
- Li, L; Xia, LR; et al. New method for fabricating an alpha-fetoprotein affinity monolithic polymer array. JOURNAL OF APPLIED POLYMER SCIENCE 132:-(2015).
- Liu, YJ; Li, JS; et al. Theranostic Polymeric Micelles for the Diagnosis and Treatment of Hepatocellular Carcinoma. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 11:613-622(2015).
