Active Recombinant Human Adrenergic, Beta-1-, Receptor, Flag-His

• Cat.No.: ADRB1-1017H

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: Flag&His
• Description: The human1-adrenoreceptor (1AR) is activated by the catecholamines epinephrine and norepinephrine and couples to the G-protein Gs to mediate adenylate cyclase activation. Theβ1AR exists as several polymorphic forms of which the Gly389 and Arg389 variants are among the best known. There is a controversy whether or not there are functional differences between the two β1AR polymorphisms. β1ARs are mainly found in the heart, kidney, and fat tissue. These receptors are involved in physiological processes such heart contraction, renin release and lipolysis. The protein contains a N-terminal FLAG-tag and a C- terminal his tag for immunological detection, to allow purification, and to provide additional protection against proteolysis.
• Form: Membrane suspension. Supplied in 75 mM Tris-HCl Ph 7.4, 12.5 mM MgCl2 and 1Mm EDTA.
• Activity: 14 pmol/mg.
• Usage: For in vitro use only.
• Storage: Quality guaranteed for 12 months store at - 80°C. Avoid freeze / thaw cycles

Gene Information

• Gene Name: ADRB1 adrenergic, beta-1-, receptor [ Homo sapiens ]
• Synonyms: ADRB1; adrenergic, beta-1-, receptor; RHR; B1AR; ADRB1R; BETA1AR;Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; OTTHUMP00000020519; beta-1-adrenergic receptor
• Gene ID: 153
• mRNA Refseq: NM_000684
• Protein Refseq: NP_000675
• MIM: 109630
• UniProt ID: P08588
• Chromosome Location: 10q24-q26
• Pathway: Calcium signaling pathway; Dilated cardiomyopathy; Endocytosis; Gap junction; Neuroactive ligand-receptor interaction
• Function: G-protein coupled receptor activity; PDZ domain binding; beta1-adrenergic receptor activity; dopamine binding; drug binding; epinephrine binding; norepinephrine binding; protein binding; receptor activity