ADAMTS2
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 2 -
Overview
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010] -
Synonyms
ADAMTS2;ADAM metallopeptidase with thrombospondin type 1 motif, 2;NPI;PNPI;PCINP;PCPNI;PCI-NP;PC I-NP;ADAM-TS2;ADAMTS-2;ADAMTS-3;A disintegrin and metalloproteinase with thrombospondin motifs 2;procollagen I N-proteinase;procollagen N-endopeptidase;procollagen I/II amino propeptide-processing enzyme;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
Recombinant Proteins
- Cattle
- Human
- Mouse
- E.coli
- Wheat Germ
- E. coli
- His
- GST
- His&SUMO
- His&Myc
- N-His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ADAMTS2-3007C | Recombinant Cattle ADAMTS2, His-tagged | E.coli | Cattle | His | 1205 |
|
| ADAMTS2-304H | Recombinant Human ADAMTS2 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| Adamts2-1757M | Recombinant Mouse Adamts2 protein, His-tagged | E.coli | Mouse | His | Val855~Pro1030 |
|
| ADAMTS2-1778H | Recombinant Human ADAMTS2 protein, His & SUMO-tagged | E.coli | Human | His&SUMO | Gln23~Pro161 |
|
| ADAMTS2-1779H | Recombinant Human ADAMTS2 Protein, His&Myc-tagged | E.coli | Human | His&Myc | 254-492aa |
|
| RBFOX1-3533H | Recombinant Human RBFOX1 protein, His-tagged | E. coli | Human | N-His | 1-128 aa |
|
| SH3BP2-4533H | Recombinant Human SH3BP2 protein, His-tagged | E. coli | Human | N-His | 401-561 aa |
|
Involved Pathway
ADAMTS2 involved in several pathways and played different roles in them. We selected most pathways ADAMTS2 participated on our site, such as Collagen biosynthesis and modifying enzymes,Collagen formation,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Collagen formation | COL4A4,COL28A1,LEPRE1,COL23A1,DST,CD151,COL8A1,COL10A1,CTSL2,COL2A1 |
| Extracellular matrix organization | SERPINH1,TPSAB1,MATN3B,COL25A1,COL15A1B,SPARC,ADAMTS3,FN1B,COL23A1,MFAP1B |
| Collagen biosynthesis and modifying enzymes | COL28A1,COL17A1,COL3A1,BMP1A,LEPREL1,PCOLCE2,PRP,LEPREL2,TLL1,COL25A1 |
Protein Function
ADAMTS2 has several biochemical functions, for example, metalloendopeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS2 itself. We selected most functions ADAMTS2 had, and list some proteins which have the same functions with ADAMTS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | RASGRP1,NR2F1B,RBM14B,RNF34,ZCCHC8,LTN1,ZDHHC16,MMP8,SF3A2,SEC24C |
| metalloendopeptidase activity | MMP8,PAPPA,ADAM18,AFG3L2,ADAM23,ADAMTS9,ADAM9,ZMPSTE24,NRD1B,PAPLN |
Interacting Protein
ADAMTS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS2.
Resources
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References
- Pyun, JA; Kim, S; et al. Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 22:212-216(2015).
- Monteagudo, LV; Ferrer, LM; et al. In silico identification and three-dimensional modelling of the missense mutation in ADAMTS2 in a sheep flock with dermatosparaxis. VETERINARY DERMATOLOGY 26:49-+(2015).
