ADAM15
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Official Full Name
ADAM metallopeptidase domain 15 -
Overview
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008] -
Synonyms
ADAM15;ADAM metallopeptidase domain 15;MDC15;disintegrin and metalloproteinase domain-containing protein 15;MDC-15;metalloprotease RGD disintegrin protein;a disintegrin and metalloproteinase domain 15 (metargidin);metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15
Recombinant Proteins
- Human
- Mouse
- Mus musculus
- HEK293
- E.coli
- CHO
- Wheat Germ
- Human Cells
- In Vitro Cell Free System
- His
- GST
- Non
Involved Pathway
ADAM15 involved in several pathways and played different roles in them. We selected most pathways ADAM15 participated on our site, such as Degradation of the extracellular matrix,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Degradation of the extracellular matrix | COL23A1,MGC174857,BMP1,CTSB,COL25A1,ADAM8,FAM49BA,MMP17,MMP20,ADAM9 |
| Extracellular matrix organization | DDR1,BGNB,TRAPPC4,COL25A1,FBLN2,COL15A1B,PTPRS,TLL1,COL6A3,ELANE |
Protein Function
ADAM15 has several biochemical functions, for example, SH3 domain binding,integrin binding,metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM15 itself. We selected most functions ADAM15 had, and list some proteins which have the same functions with ADAM15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | SFRP2,COL3A1,TSPAN4,MMP14,ADAM2,EMP2,SYK,CYR61,LAMB2,JAM3 |
| metallopeptidase activity | HE1A,GM5136,ADAM10,AGBL4,ERAP2,NPSN,PAPPA,ADAM8,MMP14B,STAMBP |
| SH3 domain binding | DTX1,ABL1,LYN,INPPL1B,PTPN12,ARHGAP1,GRIK5,ARHGAP27,SH2D2A,ITM2B |
| metalloendopeptidase activity | BMP1,ADAMTS15,C6AST1,MMP19,ADAMTS10,PAPPA,ADAM8A,MMP9,PAPPAA,PMPCB |
| protein binding | C2orf29,TMEM86B,BPIFA2,NCAPH,NF1,SKAP2,KLKB1,UBE2R2,FLT1,LRRC26 |
| zinc ion binding | YAF2,PGR,RPS29,PAPPA2,Car8,MYRIP,RBM4B,CRIP2,RNF38,RNF7 |
Interacting Protein
ADAM15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM15.
SRC;PACSIN3;FYN;HCK;GRB2;SNX9;NUP62;SP4
Resources
Research Area
ADAMs on Endothelial CellsMetalloproteases and Regulators
E-Cadherin Ectodomain Shedding and Proteolytic Processing
Matrix Remodeling Molecules
Related Services
Related Products
References
- Pasten, K; Bastian, Y; et al. ADAM15 participates in fertilization through a physical interaction with acrogranin. REPRODUCTION 148:623-634(2014).
- Grabowska, MM; Sandhu, B; et al. EGF promotes the shedding of soluble E-cadherin in an ADAM10-dependent manner in prostate epithelial cells. CELLULAR SIGNALLING 24:532-538(2012).
