ACTC1
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Official Full Name
Actin, Alpha, Cardiac Muscle 1 -
Overview
Actins are highly conserved proteins that are involved in various types of cell motility. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to four others. The protein encoded by this gene belongs to the actin family which is comprised of three main groups of actin isoforms, alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. -
Synonyms
ACTC1;actin, alpha, cardiac muscle 1;ACTC;ASD5;CMD1R;CMH11;LVNC4;OTTHUMP00000160081;alpha-cardiac actin
Recombinant Proteins
- Human
- Bovine
- Mouse
- Chicken
- Rat
- E.coli
- Bovine Heart
- Mammalian Cell
- Wheat Germ
- E.Coli or Yeast
- HEK293
- Mammalian cells
- HEK293T
- Insect cells
- Human Heart
- In Vitro Cell Free System
- Bovine cardiac muscle
- Bovine cardiac
- E. coli
- His&T7
- His
- Non
- GST
- Flag
- His&Fc&Avi
- Myc&DDK
- N-His
Involved Pathway
ACTC1 involved in several pathways and played different roles in them. We selected most pathways ACTC1 participated on our site, such as Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes,Hypertrophic cardiomyopathy (HCM), which may be useful for your reference. Also, other proteins which involved in the same pathway with ACTC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cardiac muscle contraction | COX7A2A,COX6B2,CACNG2,COX7B,CACNA2D3,UQCRC2B,CACNA2D4,TMEM8C,ATP1B4,COX7B2 |
| Dilated cardiomyopathy | MYL2,TTN,LMNA,CACNG7,ITGA9,TPM1,ATP2A2,ITGA2,CACNG2,ITGA2B |
| Adrenergic signaling in cardiomyocytes | FXYD2,KCNQ1,CACNB4A,MYL2B,ATP2A2,CREB5,ADCY3,TNNC1B,PLCB1,TNNT2 |
| Hypertrophic cardiomyopathy (HCM) | SGCG,ITGA8,ITGA5,DMD,CACNG8,ITGB3,TTN,TPM2,ITGB8,DAG1 |
Protein Function
ACTC1 has several biochemical functions, for example, ATP binding,ATPase activity,myosin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ACTC1 itself. We selected most functions ACTC1 had, and list some proteins which have the same functions with ACTC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| myosin binding | ACTA1,TRIM32,SLC6A4,CALD1,ARFGEF1,MYBPC3,SMYD1B,VAMP2,VEZT,CALM |
| ATPase activity | MYH9,KIF9,KIF2B,DNAHC8,PSMC5,MYO9B,MYO19,ATAD1A,EIF4A2,KIF4A |
| ATP binding | ACSM4,ATP5B,RECQL4,RPS6KA3,ATP10A,CAMKVB,HSP90AB1,NAV2,DGKD,KIF22 |
Interacting Protein
ACTC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACTC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACTC1.
ESR1;GAPDH;C1QTNF9;MYBPC3;TNNI3K;TRIM63;BCL11A;ASH2L;MPC1;ere_dna;MYC;VCAM1;ARRB2;HTR7;MYH9
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References
- Tian, T; Wang, JZ; et al. A low prevalence of sarcomeric gene variants in a Chinese cohort with left ventricular non-compaction. HEART AND VESSELS 30:258-264(2015).
- Chen, CD; Yu, ZQ; et al. Evaluating the Association between Pathological Myopia and SNPs in RASGRFI, ACTCI and GJD2 Genes at Chromosome 15q14 and 15q25 in a Chinese Population. OPHTHALMIC GENETICS 36:1-7(2015).
