Recombinant SARS-CoV-2 Spike protein S1 (T19R, ∆157-158, L452R, T478K, D614G, P681R) Protein, His-tagged

• Cat.No.: S-1002S
• Product Overview: Recombinant 2019-nCoV Spike protein S1 (T19R, ∆157-158, L452R, T478K, D614G, P681R) (16-685) was expressed in CHO cells using a C-terminal His-tag.

Specification

• Species: SARS-CoV-2
• Source: CHO
• Tag: His
• Protein Length: 16-685 a.a.
• Description: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) remains the most rapidly spreading disease since 2020. The spike glycoprotein (S) of coronavirus, a type I transmembrane protein containing two subunits S1 and S2, facilitates viral genome entry into the host cells through the interaction with angiotensin-converting enzyme 2 (ACE2). B.1.617, also referred to as the Indian variant, caused a surge in COVID-19 cases in India in early 2021. This variant has also been reported in UK and US. B.1.617 has 13 mutations that result in amino acid changes. These mutations include T19R, ∆157-158, L452R, T478K, D614G, P681R. As new variants displace the first-wave virus, it is pivotal to evaluate their transmissibility, virulence and their possible tendency to escape antibody neutralization.
• Molecular Mass: 76 kDa
• Purity: > 90%
• Stability: One year at -70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 1.0 μg/μL
• Storage Buffer: Recombinant protein stored in 50 mM sodium phosphate, pH 7.5, 300 mM NaCl, 150 mM imidazole.

Gene Information

• Gene Name: S surface glycoprotein [ Severe acute respiratory syndrome coronavirus 2 ]
• Official Symbol: S
• Synonyms: S; surface glycoprotein; spike glycoprotein; surface glycoprotein; structural protein; spike protein
• Gene ID: 43740568
• mRNA Refseq: MN908947
• Protein Refseq: YP_009724390