Recombinant SARS-CoV-2 S Protein, Fc-tagged

• Cat.No.: S-30S
• Product Overview: Recombinant SARS-CoV-2 (2019-nCoV) S1 Protein is produced by our Mammalian expression system and the target gene encoding Gln14-Arg685 is expressed with a Fc tag at the C-terminus.

Specification

• Species: SARS-CoV-2
• Source: Human Cells
• Tag: Fc
• Description: Protein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
• Form: Supplied as a 0.2 μm filtered solution of PBS, PH7.4.
• Molecular Mass: Predicted Molecular Weight: 102.2kDa
  Apparent Molecular Weight: 130-140kDa, reducing conditions.
• AA Sequence: Gln14-Arg685
• Endotoxin: Less than 0.1 ng/ug (1 EU/ug).
• Purity: > 85%
• Storage: Reconstituted protein solution should be stored at ≤ -20 centigrade.
• Quality Statement: Purity: Greater than 85% as determined by reducing SDS-PAGE.
• Shipping: The product is shipped on dry ice pack.

Gene Information

• Gene Name: S surface glycoprotein [ Severe acute respiratory syndrome coronavirus 2 ]
• Official Symbol: S
• Synonyms: S1 protein; 2019-nCoV S1 protein; coronavirus S1 Protein; cov S1 Protein
• Gene ID: 43740568
• Protein Refseq: YP_009724390.1
• UniProt ID: P0DTC2