Recombinant SARS-CoV-2 S Protein, Fc/Avi-tagged

• Cat.No.: S-001S
• Product Overview: Severe acute respiratory Coronavirus 2 Spike Glycoprotein S1 (SARS-CoV-2 Spike S1), a.a. 13-665, fused at the C-terminus of the Fc portion of human IgG1, with a C-terminal Avi-tag, expressed in a HEK293 expression system and enzymatically biotinylated using Avi-tag™ technology. Biotinylation is confirmed to be ≥90%.

Specification

• Species: SARS-CoV-2
• Source: HEK293
• Tag: Avi&Fc
• Protein Length: 13-665
• Description: Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection. Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.
• Molecular Mass: 102 kDa
• Purity: ≥ 90%
• Applications: Enzyme kinetics, screening inhibitors, and selectivity profiling
• Stability: ≥ 6 months
• Storage: Store at -80 centigrade
• Storage Buffer: 8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
• Warning: Avoid freeze/thaw cycles

Gene Information

• Gene Name: S spike glycoprotein [ SARS coronavirus Tor2 ]
• Official Symbol: S
• Synonyms: S; spike glycoprotein; E2; spike glycoprotein
• Gene ID: 1489668
• UniProt ID: P59594