Recombinant Rat Vascular Endothelial Growth Factor C
Cat.No. : | Vegfc-616R |
Product Overview : | Vegfc (Vascular Endothelial Growth Factor-C) is a 125 amino acid recombinant protein that lacks the N-terminal and C-terminal extensions and contains only the middle third VEGF homology domain. |
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Species : | Rat |
Source : | E.coli |
Tag : | Non |
Description : | The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-3 receptors. |
Biological Activity : | Activity of Vegfc will be tested by the stimulation of VEGF-R3 phosphorylation in cells transfected with VEGF-R3. The expected ED₅₀ is > 200 ng/ml. |
Molecular Weight : | 15.0 kDa |
Form : | Lyophilized without additives. |
Appearance : | Lyophilized protein |
Endotoxin Level : | <0.1 ng/μg |
Reconstitution : | Centrifuge the vial prior to opening. Reconstitute in 0.1% acetic acid to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70°C. |
Purity : | >90% by SDS-PAGE analyses. |
Storage : | The lyophilized Vegfc is best-stored at -20°C. Reconstituted Vegfc should be stored in working aliquots at -70°C. |
Pathways : | Bladder cancer; Cytokine-cytokine receptor interaction; Focal adhesion; Formation of Platelet plug; Hemostasis; Pancreatic cancer; Pathways in cancer; Platelet degranulation; Renal cell carcinoma; Response to elevated platelet cytosolic Ca2+; Signaling by VEGF; VEGF binds to VEGFR leading to receptor dimerization; VEGF ligand-receptor interactions; mTOR signaling pathway |
Gene Name | Vegfc vascular endothelial growth factor C [ Rattus norvegicus ] |
Official Symbol | Vegfc |
Synonyms | Vegfc; vascular endothelial growth factor C; VRP; VEGF-C; flt4-L; flt4 ligand; vascular endothelial growth factor-related protein |
Gene ID | 114111 |
mRNA Refseq | NM_053653 |
Protein Refseq | NP_446105 |
UniProt ID | O35757 |
Chromosome Location | 16p11 |
Function | chemoattractant activity; growth factor activity; vascular endothelial growth factor receptor 3 binding |
◆ Recombinant Proteins | ||
VEGFC-615H | Recombinant Human Vascular Endothelial Growth Factor C, His-tagged | +Inquiry |
Vegfc-454R | Active Recombinant Rat Vascular Endothelial Growth Factor C/VEGFC Protein | +Inquiry |
VEGFC-567H | Recombinant Human VEGFC Protein, His-tagged | +Inquiry |
VEGFC-31451TH | Recombinant Human VEGFC, Fc-tagged | +Inquiry |
Vegfc-5536R | Active Recombinant Rat Vegfc 152S Mutant Protein | +Inquiry |
◆ Cell & Tissue Lysates | ||
VEGFC-2768HCL | Recombinant Human VEGFC cell lysate | +Inquiry |
VEGFC-1306RCL | Recombinant Rat VEGFC cell lysate | +Inquiry |
Not For Human Consumption!
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