Recombinant Rat Tnfsf13b protein, His/S-tagged

Description :	B-cell activating factor, also known as BAFF, TALL-1, TNAK, and zTNF4, is a member of theTNF ligand superfamily designated TNFSF13B. Produced by macrophages, dendritic cells, and T lymphocytes, BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF 13C). These receptors are type III transmembrane proteins lacking a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL(a proliferation-inducing ligand), BAFF R selectively binds BAFF. The BAFF R extracellular domain lacks the TNF receptor canonical cysteine-rich domain (CRD) and contains only a partial CRD with four cysteine residues. Human and mouse BAFF R share 56% aa sequence identity. BAFF R is highly expressed in spleen, lymph node and resting B cells. It is also expressed at lower levels in activated B cell, resting CD4+ T cells, thymus and peripheral blood leukocytes.
Source :	E. coli
Species :	Rat
Tag :	His&S
Form :	Lyophilized from sterile PBS, pH 7.4
Purity :	> 95 % as determined by SDS-PAGE
Storage :	Store at -70 centigrade. Avoid repeated freeze/thaw cycles.

Gene Name	Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b [ Rattus norvegicus ]
Official Symbol	Tnfsf13b
Synonyms	TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor ligand superfamily member 13B; RGD1561519;
Gene ID	498666
mRNA Refseq	NM_001109112
Protein Refseq	NP_001102582
Chromosome Location	16q12.5
Pathway	Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Rheumatoid arthritis, organism-specific biosystem; Rheumatoid arthritis, conserved biosystem;
Function	tumor necrosis factor receptor binding;