Recombinant Rat Stat3 Protein, His-tagged

• Cat.No.: Stat3-2107R
• Product Overview: Recombinant Rat Stat3 Protein (Gly656-Ser768) with N-His tag was expressed in E. coli.

Specification

• Species: Rat
• Source: E.coli
• Tag: His
• Protein Length: Gly656-Ser768
• Description: Enables CCR5 chemokine receptor binding activity; glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of interleukin-6 production; and regulation of cellular biosynthetic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in mitochondrial inner membrane and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Biomarker of colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3).
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 44.7 kDa
• Purity: > 95%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: Stat3 signal transducer and activator of transcription 3 (acute-phase response factor) [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Stat3
• Synonyms: STAT3; signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer and activator of transcription 3; MGC93551
• Gene ID: 25125
• mRNA Refseq: NM_012747
• Protein Refseq: NP_036879
• UniProt ID: P52631