Recombinant Rat App Protein, His&GST-tagged

• Cat.No.: App-232R
• Product Overview: Recombinant Rat App Protein (Leu18-Val286) with N-His&GST tag was expressed in E. coli.

Specification

• Species: Rat
• Source: E.coli
• Tag: GST&His
• Protein Length: Leu18-Val286
• Description: Enables growth factor receptor binding activity and peptidase activator activity. Involved in several processes, including cellular response to metal ion; defense response to other organism; and positive regulation of MAPK cascade. Located in several cellular components, including astrocyte projection; axon; and rough endoplasmic reticulum. Used to study Alzheimer's disease. Biomarker of Alzheimer's disease; diabetic encephalopathy; hypertension; iron deficiency anemia; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein).
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 60 kDa
  Accurate Molecular Mass: 60 kDa
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1 mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: App amyloid beta (A4) precursor protein [ Rattus norvegicus (Norway rat) ]
• Official Symbol: App
• Synonyms: APP; amyloid beta (A4) precursor protein; amyloid beta A4 protein; AG; ABPP; amyloidogenic glycoprotein; alzheimer disease amyloid A4 protein homolog
• Gene ID: 54226
• mRNA Refseq: NM_019288
• Protein Refseq: NP_062161
• UniProt ID: P08592