Recombinant Rat Abat Protein, His-tagged

• Cat.No.: Abat-09R
• Product Overview: Recombinant Rat Abat Protein (Ile236-Lys500) with N-His tag was expressed in E. coli.

Specification

• Description: Enables 4-aminobutyrate transaminase activity. Involved in several processes, including gamma-aminobutyric acid biosynthetic process; positive regulation of inhibitory postsynaptic potential; and regulation of secretion. Located in mitochondrial matrix and neuron projection. Used to study several diseases, including Huntington's disease; epilepsy (multiple); heroin dependence; ischemia; and mental depression. Biomarker of Parkinsonism. Human ortholog(s) of this gene implicated in Alzheimer's disease; GABA aminotransferase deficiency; and Huntington's disease. Orthologous to human ABAT (4-aminobutyrate aminotransferase).
• Source: E. coli
• Species: Rat
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 33.8 kDa
  Accurate Molecular Mass: 34 kDa
• Protein length: Ile236-Lys500
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Abat 4-aminobutyrate aminotransferase [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Abat
• Synonyms: ABAT; 4-aminobutyrate aminotransferase; 4-aminobutyrate aminotransferase, mitochondrial; GABA-T; GABA-AT; L-AIBAT; GABA transaminase; GABA aminotransferase; gamma-amino-N-butyrate transaminase; (S)-3-amino-2-methylpropionate transaminase; Gabat; beta-AlaAT; MGC93392
• Gene ID: 81632
• mRNA Refseq: NM_031003
• Protein Refseq: NP_112265
• UniProt ID: P50554