Recombinant Ovine CXCL10 (IP-10)
Cat.No. : | CXCL10-50O |
Product Overview : | Ovine CXCL10/IP-10 was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified. |
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Species : | Ovine |
Source : | Yeast |
Tag : | Non |
Description : | C-X-C motif chemokine 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine B10 is a member of the C-X-C chemokine family. CXCL10 (IP-10) is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 (IP-10) has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL10 (IP-10) elicits its effects by binding to the cell surface chemokine receptor CXCR3. |
Form : | Lyophilized |
Molecular Mass : | 9.4 kDa |
AA Sequence : | IPLSRNTRCT CIEISNGSVN PRSLEKLELI PASQSCPRVE IIATMKRNGE KRCLNPESKT IKNLLKAINK QRTKRSPRTQ KEA (83) |
Applications : | The Ovine CXCL10/IP-10 protein can be used in cell culture, as an CXCL10/IP-10 ELISA Standard, and as a Western Blot Control. |
Storage : | -20 C |
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Not For Human Consumption!
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