Recombinant Norovirus GII.4 VP1 antigen

• Cat.No.: VP1-16N
• Product Overview: Recombinant Norovirus GII.4 VP1 antigen produced in mammalian HEK293 cells.

Specification

• Species: Norovirus GII.4
• Source: HEK293
• Protein Length: 1-539 aa
• Description: Norovirus VP1 protein is the capsid protein of Norovirus. It is a 59kD glycoprotein with three key domains. The shell domain (S domain) contains elements essential for the formation of the icosahedron. The Protruding domain (P domain) is divided into sub-domains P1 and P2. P domain interacts in dimeric contacts that increase the stability of the capsid and form the protrusions on the virion. An hypervariable region in P2 is thought to play an important role in receptor binding and immune reactivity.
• Form: Liquid
• Molecular Mass: 59 kDa
• Purity: Greater than 95% purity by SDS-PAGE.
• Storage: Short Term Storage: 4 centigrade
  Long Term Storage: -80 centigrade
  Freezing: Can be frozen and thawed at least 5 times.
• Concentration: 1.0 mg/ml, according to BCA test method using BSA standards.
• Storage Buffer: 20mM Tris-HCl pH 7.8, 10mM NaCl.
• References: Karst SM. (2010). Pathogenesis of noroviruses, emerging RNA viruses. Viruses.Mar;2(3):748-81. PMID: 21994656
  Robilotti E, Deresinski S, Pinsky BA. (2015). Norovirus. Clin Microbiol Rev.Jan;28(1):134-64. PMID: 25567225
  Centers for disease control and prevention: Norovirus, Clinical overview
  Centers for disease control and prevention: Norovirus, Burden of norovirus illness and outbreaks
  Takeda press release: Takeda initiates world's first norovirus vaccine field trial

Gene Information

• Gene Name: ORF2 VP1 [ Norovirus GII ]
• Official Symbol: VP1
• Synonyms: VP1; D9V40_gp2; ORF2
• Gene ID: 39105315
• Protein Refseq: YP_009518842.1
• UniProt ID: Q83884