Recombinant Mouse Txnip Protein, Myc/DDK-tagged

• Cat.No.: Txnip-6750M
• Product Overview: Purified recombinant protein of mouse full-length thioredoxin interacting protein (Txnip), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
• Molecular Mass: 44.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Txnip thioredoxin interacting protein [ Mus musculus (house mouse) ]
• Official Symbol: Txnip
• Synonyms: TXNIP; thioredoxin interacting protein; thioredoxin-interacting protein; hyperlipidemia 1; thioredoxin binding protein-2; vitamin D3 up-regulated protein 1; upregulated by 1,25-dihydroxyvitamin D-3; THIF; Tbp-2; VDUP1; Hyplip1; AA682105; 1200008J08Rik
• Gene ID: 56338
• mRNA Refseq: NM_023719
• Protein Refseq: NP_076208
• UniProt ID: Q8BG60