Recombinant Mouse Tnfrsf18, Fc Chimera

• Cat.No.: Tnfrsf18-2087M
• Product Overview: Recombinant MouseTnfrsf18 Produced inHEK 293 cells.The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1. MW=45kDa (SDS-PAGE).

Specification

• Species: Mouse
• Source: HEK293
• Tag: Fc
• Protein Length: 20-152 a.a.
• Description: GITR (glucocorticoid-induced tumor necrosis factor receptor) also known as TNFRSF18, is a surface receptor molecule that has been shown to be involved in inhibiting the suppressive activity of T-regulatory cells and extending the survival of T-effector cells.1 GITR is involved in the regulation of T-cell receptor mediated cell death. Constitutive expression of a transfected GITR gene induces resistance to apoptosis induced by anti CD3 monoclonal antibodies.
• Concentration: 1mg/ml after reconstitution.
• Purity: ≥90% (SDS-PAGE).
• Formulation: Lyophilized. Contains PBS.
• Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
• Reconstitution: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
• Specificity: Binds mouse GITRL.
• Term Storage: -20°C.
• Handling: Stable for at least 6 months after receipt when stored at -20°C.
• Stability: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

Gene Information

• Gene Name: Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 [ Mus musculus ]
• Synonyms: Tnfrsf18; tumor necrosis factor receptor superfamily, member 18; AITR; Gitr;tumor necrosis factor receptor superfamily member 18; OTTMUSP00000011817; OTTMUSP00000011818; glucocorticoid-induced TNFR-related protein
• Gene ID: 21936
• mRNA Refseq: NM_009400
• Protein Refseq: NP_033426
• UniProt ID: O35714
• Chromosome Location: 4 E
• Pathway: Cytokine-cytokine receptor interaction
• Function: protein binding; receptor binding