Recombinant Mouse Thoc6 Protein, Myc/DDK-tagged

• Cat.No.: Thoc6-6414M
• Product Overview: Purified recombinant protein of mouse full-length THO complex 6 (Thoc6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway.Plays a role in apoptosis negative control involved in brain development.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 37.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Thoc6 THO complex 6 [ Mus musculus (house mouse) ]
• Official Symbol: Thoc6
• Synonyms: THOC6; THO complex 6 homolog (Drosophila); THO complex subunit 6 homolog; WD repeat domain 58; WD repeat-containing protein 58; Wdr58; F830014G06Rik; MGC107304; MGC109691
• Gene ID: 386612
• mRNA Refseq: NM_001008425
• Protein Refseq: NP_001008425
• UniProt ID: Q5U4D9