Recombinant Mouse Tbc1d5 Protein, Myc/DDK-tagged

• Cat.No.: Tbc1d5-6309M
• Product Overview: Purified recombinant protein of mouse full-length TBC1 domain family, member 5 (Tbc1d5), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: May act as a GTPase-activating protein for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 92.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tbc1d5 TBC1 domain family, member 5 [ Mus musculus (house mouse) ]
• Official Symbol: Tbc1d5
• Synonyms: Tbc1d5; TBC1 domain family, member 5; 1600014N05Rik; TBC1 domain family member 5
• Gene ID: 72238
• mRNA Refseq: NM_028162
• Protein Refseq: NP_082438
• UniProt ID: Q80XQ2