Recombinant Mouse Snx17 Protein, Myc/DDK-tagged

• Cat.No.: Snx17-6025M
• Product Overview: Purified recombinant protein of mouse full-length sorting nexin 17 (Snx17), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
• Molecular Mass: 52.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Snx17 sorting nexin 17 [ Mus musculus (house mouse) ]
• Official Symbol: Snx17
• Synonyms: SNX17; sorting nexin 17; sorting nexin-17; AI790646; mKIAA0064; D5Ertd260e; 5830447M19Rik
• Gene ID: 266781
• mRNA Refseq: NM_153680
• Protein Refseq: NP_710147
• UniProt ID: Q8BVL3