Recombinant Mouse Slc2a1 Protein, Myc/DDK-tagged

• Cat.No.: Slc2a1-5919M
• Product Overview: Purified recombinant protein of mouse full-length solute carrier family 2 (facilitated glucose transporter), member 1 (Slc2a1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 54 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 [ Mus musculus (house mouse) ]
• Official Symbol: Slc2a1
• Synonyms: SLC2A1; solute carrier family 2 (facilitated glucose transporter), member 1; solute carrier family 2, facilitated glucose transporter member 1; GT1; solute carrier family 2, member 1; glucose transporter type 1, erythrocyte/brain; Glut1; Glut-1
• Gene ID: 20525
• mRNA Refseq: NM_011400
• Protein Refseq: NP_035530
• UniProt ID: P17809

Reviews

07/10/2021

Quality product, great results.

09/14/2020

Fast and efficient service.

02/13/2018

Excellent for immunofluorescence.

Q&As

What is the main function of SLC2A1 in cellular glucose transport?

SLC2A1 facilitates the passive transport of glucose across cell membranes, especially in conditions of low glucose concentration.

What specific substrates can SLC2A1 transport in addition to glucose?

Besides glucose, SLC2A1 can also transport other hexoses such as galactose.

How is SLC2A1 expression regulated under varying glucose conditions?

SLC2A1 expression is upregulated in response to low glucose availability to ensure sufficient glucose uptake.

What potential therapeutic interventions could target SLC2A1?

Therapeutic interventions could involve managing glucose levels and ketogenic diets to bypass the glucose transport defect in conditions like GLUT1 deficiency syndrome.

In which tissues is SLC2A1 predominantly expressed?

It is ubiquitously expressed but is particularly prevalent in erythrocytes and the endothelial cells of the blood-brain barrier.

What happens when there are mutations or dysregulations in SLC2A1?

Mutations or dysregulations in SLC2A1 can lead to glucose transport deficiencies, affecting energy supply to cells.

Has SLC2A1 been linked to any specific diseases or conditions?

Mutations in SLC2A1 are associated with GLUT1 deficiency syndrome, which can result in epilepsy, developmental delay, and movement disorders.