Recombinant Mouse Sele Protein, His-tagged

• Cat.No.: Sele-2048M
• Product Overview: Recombinant Mouse Sele Protein (Trp22-Leu371) with N-His tag was expressed in E. coli.

Specification

• Description: Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling. Acts upstream of or within positive regulation of leukocyte migration. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including adrenal gland; genitourinary system; incisor; integumental system; and limb segment. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E).
• Source: E. coli
• Species: Mouse
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 68.7 kDa
  Accurate Molecular Mass: 69 kDa
• Protein length: Trp22-Leu371
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Sele selectin, endothelial cell [ Mus musculus (house mouse) ]
• Official Symbol: Sele
• Synonyms: SELE; selectin, endothelial cell; E-selectin; ELAM-1; LECAM2; CD62 antigen-like family member E; endothelial leukocyte adhesion molecule 1; leukocyte-endothelial cell adhesion molecule 2; Elam; CD62E
• Gene ID: 20339
• mRNA Refseq: NM_011345
• Protein Refseq: NP_035475
• UniProt ID: Q00690

Reviews

11/26/2020

With its remarkable purity and reliability, coupled with the manufacturer's excellent technical support, this protein is a crucial asset in addressing my scientific inquiries and advancing my research goals.

09/08/2019

In addition to its outstanding quality, the SELE Protein exhibits exceptional stability during storage and usage.

06/16/2019

Its ability to maintain structural integrity and stability ensures accurate imaging, enabling me to gain deeper insights into the three-dimensional organization and interactions of the proteins under investigation.

Q&As

Is there a diagnostic test to measure SELE levels in patients?

Some diagnostic tests can measure SELE levels in the blood, providing insights into the inflammatory status of an individual.

Can SELE protein be involved in cancer progression?

Emerging research suggests a potential role of SELE in cancer metastasis, making it a target for investigation in cancer therapy.

Are there any genetic factors influencing SELE expression?

Genetic variations can influence SELE expression, contributing to individual differences in inflammatory responses.

How does SELE protein interact with circulating immune cells?

SELE binds to specific receptors on immune cells, facilitating their adhesion to endothelial cells and promoting their migration to inflammatory sites.

Can targeting SELE protein be a potential strategy for anti-inflammatory therapies?

Yes, drugs designed to modulate SELE activity are being explored as potential anti-inflammatory agents.