Recombinant Full Length Mouse Ripk1 protein, His-tagged

• Cat.No.: RIPK1-14243M
• Product Overview: Recombinant Mouse Ripk1(1-656aa) fused with His tag was expressed in HEK293.

Specification

• Description: Ripk1 played an imporant role in many functions.
• Source: HEK293
• Species: Mouse
• Tag: His
• Form: Sterile 10mM Tris-HCl, 1mM EDTA, pH8.0, 50% glycerol.
• Molecular Mass: 76 kDa
• Protein length: 1-656aa
• AA Sequence: MQPDMSLDNI KMASSDLLEK TDLDSGGFGK VSLCYHRSHG FVILKKVYTG PNRAEYNEVL
  LEEGKMMHRL RHSRVVKLLG IIIEEGNYSL VMEYMEKGNL MHVLKTQIDV PLSLKGRIIV
  EAIEGMCYLH DKGVIHKDLK PENILVDRDF HIKIADLGVA SFKTWSKLTK EKDNKQKEVS
  STTKKNNGGT LYYMAPEHLN DINAKPTEKS DVYSFGIVLW AIFAKKEPYE NVICTEQFVI
  CIKSGNRPNV EEILEYCPRE IISLMERCWQ AIPEDRPTFL GIEEEFRPFY LSHFEEYVEE
  DVASLKKEYP DQSPVLQRMF SLQHDCVPLP PSRSNSEQPG SLHSSQGLQM GPVEESWFSS
  SPEYPQDEND RSVQAKLQEE ASYHAFGIFA EKQTKPQPRQ NEAYNREEER KRRVSHDPFA
  QQRARENIKS AGARGHSDPS TTSRGIAVQQ LSWPATQTVW NNGLYNQHGF GTTGTGVWYP
  PNLSQMYSTY KTPVPETNIP GSTPTMPYFS GPVADDLIKY TIFNSSGIQI GNHNYMDVGL
  NSQPPNNTCK EESTSRHQAI FDNTTSLTDE HLNPIRENLG RQWKNCARKL GFTESQIDEI
  DHDYERDGLK EKVYQMLQKW LMREGTKGAT VGKLAQALHQ CCRIDLLNHL IRASQS
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: > 90 % as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade.
• Storage: Store it under sterile conditions at -20 centigrade~-70 centigrade. It is recommended that the protein be aliquoted for
  optimal storage. Avoid repeated freeze-thaw cycles.
• Concentration: 1.0mg/ml

Gene Information

• Gene Name: Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 [ Mus musculus ]
• Official Symbol: Ripk1
• Synonyms: RIPK1; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor-interacting serine/threonine-protein kinase 1; RIP-1; cell death protein RIP; receptor-interacting protein 1; serine/threonine-protein kinase RIP; RIP; Rinp; Rip1; D330015H01Rik
• Gene ID: 19766
• mRNA Refseq: NM_009068
• Protein Refseq: NP_033094
• UniProt ID: Q60855
• Chromosome Location: 13 A3.3; 13 14.01 cM
• Pathway: Activation of Pro-Caspase 8, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Apoptosis, organism-specific biosystem; Apoptosis Modulation by HSP70, organism-specific biosystem; Apoptosis signaling pathway, organism-specific biosystem
• Function: ATP binding; death domain binding; death receptor binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity; transferase activity, transferring phosphorus-containing groups

Reviews

02/26/2022

The proteins accepted were of very high purity and were put into experiments with satisfactory results.

03/14/2021

Customer service was patient, prompt and accurate in answering my queries.

11/23/2020

Prompt delivery, which helped me to obtain satisfactory experimental results in a short time.

Q&As

What is the relationship between RIPK1 and necrotic apoptosis?

RIPK1 is one of the most critical intracellular signaling factors mediating necrotic apoptosis.

What is the relationship between Necrostatin-1 and RIPK1?

Necrostatin-1 blocks RIPK1 phosphorylation.

What are the effects of inhibiting RIPK1 expression?

Inhibition of RIPK1 reduces astrocyte proliferation and glial scar formation and promotes recovery of brain function.

RIPK1 is closely associated with the study of which diseases?

RIPK1 is closely related to the study of stroke, neurodegenerative diseases, autoimmune diseases and other diseases.