Recombinant Mouse Pcdh8 Protein, Myc/DDK-tagged

• Cat.No.: Pcdh8-4706M
• Product Overview: Purified recombinant protein of mouse full-length protocadherin 8 (Pcdh8), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a type I transmembrane protein composed of an extracellular domain including 6 cadherin ectodomains, a single-pass transmembrane domain and a cytoplasmic tail. Unlike classical cadherins, which are generally encoded by 15-17 exons, this gene includes only 3 exons with the first large exon encoding the extracellular and transmembrane region. Although this gene product is capable of homophilic interaction, it appears to affect cell-cell adhesion indirectly by initiating signaling events that regulate classical cadherin-mediated adhesion. Based on studies on this protein and its orthologs, this protocadherin mainly functions in developing embryos and the central nervous system, but can also function as a tumor suppressor. Alternative splicing yielding isoforms with unique cytoplasmic tails has been reported.
• Molecular Mass: 113.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pcdh8 protocadherin 8 [ Mus musculus (house mouse) ]
• Official Symbol: Pcdh8
• Synonyms: PCDH8; protocadherin 8; protocadherin-8; arcadlin; paraxial protocadherin; Papc; 1700080P15Rik
• Gene ID: 18530
• mRNA Refseq: NM_021543
• Protein Refseq: NP_067518
• UniProt ID: Q7TSK3