Recombinant Mouse Ncstn Protein, Myc/DDK-tagged

• Cat.No.: Ncstn-4319M
• Product Overview: Purified recombinant protein of mouse full-length nicastrin (Ncstn), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
• Molecular Mass: 78.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ncstn nicastrin [ Mus musculus (house mouse) ]
• Official Symbol: Ncstn
• Synonyms: NCSTN; nicastrin; Nct; Aph2; AA727311; D1Dau13e; Kiaa0253; mKIAA0253; 9430068N19Rik
• Gene ID: 59287
• mRNA Refseq: NM_021607
• Protein Refseq: NP_067620
• UniProt ID: P57716