Recombinant Mouse Itm2c Protein, Myc/DDK-tagged

• Cat.No.: Itm2c-3617M
• Product Overview: Purified recombinant protein of mouse full-length integral membrane protein 2C (Itm2c), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.
• Molecular Mass: 30.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Itm2c integral membrane protein 2C [ Mus musculus (house mouse) ]
• Official Symbol: Itm2c
• Synonyms: ITM2C; integral membrane protein 2C; transmembrane protein BRI3; integral membrane protein 3; E25; BRI3; E25C; ITM3; 3110038L02Rik
• Gene ID: 64294
• mRNA Refseq: NM_022417
• Protein Refseq: NP_071862
• UniProt ID: Q91VK4