Recombinant Mouse Interleukin 18 Receptor 1, His-tagged

• Cat.No.: Il18r1-2207M
• Product Overview: Recombinant mouse IL18R1 produced inhuman cellsencoding the extracellular domain of mouse IL18R1 (Met 1-Gly 326) was expressed, fused with a his tag at the C-terminus.

Specification

• Species: Human
• Source: Human Cells
• Tag: His
• Protein Length: 1-326 a.a.
• Description: The interleukin-18 receptor 1 (IL18R1), also known as CDw218a (cluster of differentiation w218a), is a cytokine receptor that belongs to the interleukin 1 receptor family, and a single-pass type Ⅰmembrane protein contining three Ig-ike C2-type domains within the ECD. It specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction, and it is reported that binding to the agonist leads to the activation of NF-kappa-B. IL-18 receptor was first described in 1989. It induces synthesis and release of IFN-gamma, IL- 8, 4 and 13, TNF-alpha and granulocyte/macrophage colony stimulating factor (GM-CSF). It modulates the function of many immunocompetent cells including macrophages, monocytes, lymphocytes and granulocytes. Another feature of IL-18 receptor is its ability to induce apoptosis of many cell types by inducing Fas ligand and receptor, aas well as granzymes. High level of IL18R1 expression is detected in Hodgkin"s disease cell lines.
• Purity: > 98 % as determined by SDS-PAGE.
• Formulation: Supplied as a 0.2μm filtered solution of PBS , pH 7.4.
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Predicted N Terminal: Lys 20.
• Molecular Mass: The recombinant mouse IL18R1 consists of 318 amino acids after removal of the signal peptide and has a predicted molecular mass of 36.8 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm IL18R1 is approximately 65-75 kDa due to glycosylation.
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃.
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: Il18r1 interleukin 18 receptor 1 [ Mus musculus ]
• Synonyms: interleukin 18 receptor 1; Il1rrp; Il18ralpha; Il18r1; interleukin-18 receptor 1; IL-18R1; IL-1Rrp; IL1R-rp; IL-18R-1; IL1 receptor-related protein; CD218 antigen-like family member A; interleukin 1 receptor related protein
• Gene ID: 16182
• mRNA Refseq: NM_001161842
• Protein Refseq: NP_001155314
• UniProt ID: Q61098
• Chromosome Location: 1 B
• Pathway: Cytokine-cytokine receptor interaction
• Function: receptor activity; transmembrane receptor activity