Recombinant Mouse Frs2 Protein, Myc/DDK-tagged

• Cat.No.: Frs2-3087M
• Product Overview: Purified recombinant protein of mouse full-length fibroblast growth factor receptor substrate 2 (Frs2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
• Molecular Mass: 57.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Frs2 fibroblast growth factor receptor substrate 2 [ Mus musculus (house mouse) ]
• Official Symbol: Frs2
• Synonyms: FRS2; fibroblast growth factor receptor substrate 2; SNT-1; FRS2-alpha; FGFR substrate 2; FGFR-signaling adaptor SNT; suc1-associated neurotrophic factor target 1; SNT1; Frs2alpha; 4732458E18; C330018A15Rik
• Gene ID: 327826
• mRNA Refseq: NM_177798
• Protein Refseq: NP_808466
• UniProt ID: Q8C180