Recombinant Mouse Fgfr1 Protein, Myc/DDK-tagged

• Cat.No.: Fgfr1-3000M
• Product Overview: Purified recombinant protein of mouse full-length fibroblast growth factor receptor 1 (Fgfr1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
• Molecular Mass: 92.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Fgfr1 fibroblast growth factor receptor 1 [ Mus musculus (house mouse) ]
• Official Symbol: Fgfr1
• Synonyms: FGFR1; fibroblast growth factor receptor 1; MFR; c-fgr; bFGF-R-1; proto-oncogene c-Fgr; basic fibroblast growth factor receptor 1; FLG; Eask; Hspy; Flt-2; Fgfr-1; AW208770
• Gene ID: 14182
• mRNA Refseq: NM_010206
• Protein Refseq: NP_034336
• UniProt ID: P16092