Recombinant Mouse Fbxo3 Protein, Myc/DDK-tagged

• Cat.No.: Fbxo3-2966M
• Product Overview: Purified recombinant protein of mouse full-length F-box protein 3 (Fbxo3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation.
• Molecular Mass: 47.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Fbxo3 F-box protein 3 [ Mus musculus (house mouse) ]
• Official Symbol: Fbxo3
• Synonyms: FBXO3; F-box protein 3; F-box only protein 3; F-box protein FBA; Fba; AI046358; 1200002G09Rik; 1700026K02Rik
• Gene ID: 57443
• mRNA Refseq: NM_020593
• Protein Refseq: NP_065618
• UniProt ID: Q9DC63