Recombinant Mouse Dpf1 Protein, Myc/DDK-tagged

• Cat.No.: Dpf1-2633M
• Product Overview: Purified recombinant protein of mouse full-length D4, zinc and double PHD fingers family 1 (Dpf1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 44.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Dpf1 D4, zinc and double PHD fingers family 1 [ Mus musculus (house mouse) ]
• Official Symbol: Dpf1
• Synonyms: Dpf1; D4, zinc and double PHD fingers family 1; Neud; Neud4; neuro; zinc finger protein neuro-d4; BAF45B; BRG1-associated factor 45B; neuro-d4; neuronal d4 domain family member
• Gene ID: 29861
• mRNA Refseq: NM_013874
• Protein Refseq: NP_038902
• UniProt ID: Q9QX66