Recombinant Mouse Crk Protein, Myc/DDK-tagged

• Cat.No.: Crk-2313M
• Product Overview: Purified recombinant protein of mouse full-length v-crk avian sarcoma virus CT10 oncogene homolog (Crk), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: This gene is part of a family of adapter proteins that mediate formation of signal transduction complexes in response to extracellular stimuli, such as growth and differentiation factors. Protein-protein interactions occur through the SH2 domain, which binds phosphorylated tyrosine residues, and the SH3 domain, which binds proline-rich peptide motifs. These interactions promote recruitment and activation of effector proteins to regulate cell migration, adhesion, and proliferation. In mouse this protein is essential for embryonic development. Alternatively spliced transcripts encoding different isoforms with distinct biological activity have been described.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 33.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Crk v-crk avian sarcoma virus CT10 oncogene homolog [ Mus musculus (house mouse) ]
• Official Symbol: Crk
• Synonyms: CRK; v-crk sarcoma virus CT10 oncogene homolog (avian); adapter molecule crk; p38; proto-oncogene c-crk; CT-10 related kinase 3; v-crk sarcoma virus CT10 oncogene-like protein; avian sarcoma virus CT10 (v-crk) oncogene homolog; Crk3; Crko; Crk-I; Crkol; Crk-II; CrkIII; Crk-III
• Gene ID: 12928
• mRNA Refseq: NM_133656
• Protein Refseq: NP_598417
• UniProt ID: Q64010