Recombinant Mouse Cracr2a Protein, Myc/DDK-tagged

• Cat.No.: Cracr2a-2303M
• Product Overview: Purified recombinant protein of mouse full-length calcium release activated channel regulator 2A (Cracr2a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Ca2+-binding protein that plays a key role in store-operated Ca2+ entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+ concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+ resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
• Molecular Mass: 35.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Cracr2a calcium release activated channel regulator 2A [ Mus musculus (house mouse) ]
• Official Symbol: Cracr2a
• Synonyms: Cracr2a; calcium release activated channel regulator 2A; Gm462; Efcab4; Gm1073; Efcab4b; EF-hand calcium-binding domain-containing protein 4B; EF-hand calcium binding domain 4B
• Gene ID: 381812
• mRNA Refseq: NM_001033464
• Protein Refseq: NP_001028636
• UniProt ID: Q3UP38