Recombinant Mouse Chac1 Protein, Myc/DDK-tagged

• Cat.No.: Chac1-2134M
• Product Overview: Purified recombinant protein of mouse full-length ChaC, cation transport regulator 1 (Chac1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 24.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Chac1 ChaC, cation transport regulator 1 [ Mus musculus (house mouse) ]
• Official Symbol: Chac1
• Synonyms: Chac1; ChaC, cation transport regulator 1; Botc; 1810008K03Rik; glutathione-specific gamma-glutamylcyclotransferase 1; ChaC, cation transport regulator-like 1; blocks Notch protein; botch; cation transport regulator-like protein 1; gamma-GCG 1; EC 4.3.2.7
• Gene ID: 69065
• mRNA Refseq: NM_026929
• Protein Refseq: NP_081205
• UniProt ID: Q8R3J5