Recombinant Mouse Cd274 Protein, Fc-tagged

• Cat.No.: Cd274-2059M
• Product Overview: Purified recombinant protein of mouse PD-L1 / CD274 (PD-L1 / CD274), with C-terminal Fc tag, expressed in human cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: Fc
• Protein Length: Phe19-Thr238
• Description: The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis.
• Molecular Mass: 50 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: PBS, pH 7.4, 10% glycerol

Gene Information

• Gene Name: Cd274 CD274 antigen [ Mus musculus (house mouse) ]
• Official Symbol: Cd274
• Synonyms: Cd274; CD274 antigen; PD-; B7h1; Pdl1; Pdcd1l; Pdcd1l1; Pdcd1lg1; A530045L16Rik
• Gene ID: 60533
• mRNA Refseq: NM_021893
• Protein Refseq: NP_068693
• UniProt ID: Q9EP73