Recombinant Mouse Calcoco1 Protein, Myc/DDK-tagged

• Cat.No.: Calcoco1-1935M
• Product Overview: Purified recombinant protein of mouse full-length calcium binding and coiled coil domain 1 (Calcoco1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells.
• Molecular Mass: 77.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Calcoco1 calcium binding and coiled coil domain 1 [ Mus musculus (house mouse) ]
• Official Symbol: Calcoco1
• Synonyms: CALCOCO1; calcium binding and coiled coil domain 1; calcium-binding and coiled-coil domain-containing protein 1; GRIP1-interacting protein; coiled-coil coactivator protein; granule cell antiserum positive 11; coiled-coil transcriptional coactivator; Cocoa; Gcap11; mKIAA1536; 1810009B06Rik; KIAA1536
• Gene ID: 67488
• mRNA Refseq: NM_026192
• Protein Refseq: NP_080468
• UniProt ID: Q8CGU1