Recombinant Mouse Asz1 Protein, Myc/DDK-tagged

• Cat.No.: Asz1-1756M
• Product Overview: Purified recombinant protein of mouse full-length ankyrin repeat, SAM and basic leucine zipper domain containing 1 (Asz1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc&DDK
• Molecular Mass: 53 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Asz1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 [ Mus musculus (house mouse) ]
• Official Symbol: Asz1
• Synonyms: ASZ1; ankyrin repeat, SAM and basic leucine zipper domain containing 1; ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1; germ cell-specific ankyrin, SAM and basic leucine zipper domain containing protein; germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein; Gasz; ORF3; 4933400N19Rik
• Gene ID: 74068
• mRNA Refseq: NM_023729
• Protein Refseq: NP_076218
• UniProt ID: Q8VD46