Recombinant Influenza A virus NA Protein, His-tagged

• Cat.No.: NA-02I
• Product Overview: This Influenza virus neuraminidase protein is derived from the NA sequence of the A/Darwin/9/2021 (H3N2)-like virus, expressing aa 31-469, and fused with a polyhistidine tag at the C-terminus. The influenza virus neuraminidase protein is expressed in HEK293 cells. This virus is recommended by WHO for inclusion in the quadrivalent and trivalent vaccines for use in the 2022 southern hemisphere influenza season. (Accession: GISAID EPI1917566)

Specification

• Species: Influenza A virus (A/Darwin/9/2021)
• Source: HEK293
• Tag: His
• Protein Length: 31-469 a.a.
• Description: The influenza A viruses are negative-sense, single-stranded, segmented RNA viruses of the genus Alphainfluenzavirus, family Orthomyxoviridae. There are several subtypes, named according to the type of Haemagglutinin (H1-18) and Neuraminidase (N1-11) (Centers for Disease Control and Prevention, 2017). Humans are generally infected by influenza viruses of the subtypes H1, H2 or H3, and N1 or N2. In April 2009, a new virus, referred to as A/(H1N1) pdm09, appeared in Mexico and California (US), and was responsible for the first pandemics of the 21st century (claiming several hundred lives). It spreads rapidly from person to person, and is not related to any circulating inter-pandemic viruses. It is a quadruple reassortant virus, consisting of two swine-origin viruses, one avian-origin virus and one human-origin virus. It has a high fatality rate and shows higher incidence among younger people. WHO convenes technical consultations in February and September each year to recommend viruses for inclusion in influenza vaccines for the northern and southern hemisphere influenza seasons, respectively.
• Form: Liquid
• Molecular Mass: Expected Molecular Weight: 50 kDa
  Observed Molecular Weight: 75 kDa
• Purity: > 95 %
• Storage: Short Term Storage: -80 centigrade
  Long Term Storage: -80 centigrade
  Freezing: Can be frozen, but avoid multiple freeze-thaw cycles.
• Storage Buffer: DPBS
• Shipping: Dry ice